治験は「単心室症」の子供が対象。左右ある心室が生まれつき１つしかない難病で、血管を下大静脈と肺につなぎ血液を肺に送るバイパス手術をする。
患者の骨髄から血管の再生につながる細胞を採取し培養。生分解性の管に付けて人工血管にした。患者に移植すると半年から９カ月で本物の血管
になる。生分解性材料は体内で無くなり、完全に置き換わる。エール大は11年夏、単心室症の１人に手術し、経過は順調という。８月までに、さらに５人で効果や副作用の有無を調べる。
現在はスポーツ衣料などに使う素材でできた人工血管を使うが、血栓を防ぐ薬を服用する。成長に合わせて血管を移植し直す必要もあった。
グンゼは人工血管を中心とする再生医療を事業の柱に育てる考え。許認可のスピードが速い米国でのデータを他国での承認に生かす方針だ。心臓病だけでなく他の病状にも適応できると思いますので治験を進めて早く実用化して欲しいですね。
Gunze began in the U.S. (trials) to play the vascular clinical trials based on bone marrow cells taken from Yale University and a pair of patients, to treat the incurable disease of the heart. Because it uses the patient's own cells, rejection is less likely to occur, can also be difficult (thrombosis) blood clot. Approved by the U.S. Food and Drug Administration (FDA), commercialization of regenerative medicine aim of blood vessels by 2017. Clinical trial using a vessel made with the patient's own cells is called the world's first.
For children of "single ventricle disease" investigational. Incurable disease in which there is only one innate right and left ventricle, bypass surgery to connect to send blood to the lungs and pulmonary blood vessels inferior vena cava.
Cultured cells were harvested from the bone marrow lead to regeneration of the blood vessels of the patient. Artificial blood vessel was in the tubes with the biodegradable. Blood vessels become real in nine months from six months when transplanted to the patient. Biodegradable materials are no longer in the body, a complete replacement. Yale in the summer 11 years, the surgery to one of the single ventricle disease, well that elapsed. By August, the presence or absence of adverse effects and examine five more people.
Although currently use the artificial blood vessel made of material used, such as sportswear, to take medicine to prevent blood clots. There was also need to re-transplant blood vessels as they grow.
Gunze is thought to raise the pillars of the regenerative medicine business with a focus on artificial blood vessels. Plans approved in other countries to take advantage of the speed of approval in the U.S. data is faster. I want to promote commercialization and early clinical trials so I think that can also be applied to other medical conditions as well as heart disease.
Gunze began in the U.S. (trials) to play the vascular clinical trials based on bone marrow cells taken from Yale University and a pair of patients, to treat the incurable disease of the heart. Because it uses the patient's own cells, rejection is less likely to occur, can also be difficult (thrombosis) blood clot. Approved by the U.S. Food and Drug Administration (FDA), commercialization of regenerative medicine aim of blood vessels by 2017. Clinical trial using a vessel made with the patient's own cells is called the world's first.
For children of "single ventricle disease" investigational. Incurable disease in which there is only one innate right and left ventricle, bypass surgery to connect to send blood to the lungs and pulmonary blood vessels inferior vena cava.
Cultured cells were harvested from the bone marrow lead to regeneration of the blood vessels of the patient. Artificial blood vessel was in the tubes with the biodegradable. Blood vessels become real in nine months from six months when transplanted to the patient. Biodegradable materials are no longer in the body, a complete replacement. Yale in the summer 11 years, the surgery to one of the single ventricle disease, well that elapsed. By August, the presence or absence of adverse effects and examine five more people.
Although currently use the artificial blood vessel made of material used, such as sportswear, to take medicine to prevent blood clots. There was also need to re-transplant blood vessels as they grow.
Gunze is thought to raise the pillars of the regenerative medicine business with a focus on artificial blood vessels. Plans approved in other countries to take advantage of the speed of approval in the U.S. data is faster. I want to promote commercialization and early clinical trials so I think that can also be applied to other medical conditions as well as heart disease.
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