And create a mass of cells resembling iPS cells by the addition of compound.

That it has created a mass of cells that is similar to (iPS cells) induced pluripotent stem cells by the cells of the human skin , compounds are added , the team of ( chemical biology ) Sugiyama, professor of Kyoto University said on Tuesday the 24th . Making it normally , such as the introduction of four genes called " the mountains four factor" to the cells of the skin iPS cells .
This time , pluripotent that changes in various cells of the body is untested, but if Rarere sure the iPS cells , it is a new production method that does not use gene . Professor Sugiyama said, " and features iPS cells are similar . Promote further validation " he said. Of submitted papers of research results .
By processing the therapeutic agents of malignant lymphoma , the team developed a compound of about 30 types that can actively functions of specific genes . iPS cells , with properties such as fertilized eggs have the ability to change into a variety of cells and tissues .
Check out which compound , the team , in addition to the one by one skin cells the compound , and to active the function of genes involved in changes to the state of the cell close to the fertilized egg has identified the one for this . They cultured in addition to the skin cells to the compounds , mass of cells , such as iPS cells can be from about 3 weeks . There enzymes and specific , and proliferative capacity as high as in iPS cells , it looks that are similar .
I hope there will be a need to verify in detail whether the iPS cells for practical use , but iPS cells and will be able to without using the gene .



ヒトの皮膚の細胞に、化合物を加えることで人工多能性幹細胞（ｉＰＳ細胞）に似た細胞の塊を作ったと、京都大の杉山教授（ケミカルバイオロジー）のチームが２４日明らかにした。ｉＰＳ細胞は通常、皮膚の細胞に「山中４因子」という４つの遺伝子を導入するなどして作る。
　今回、体のさまざまな細胞に変化する多能性は未確認だが、ｉＰＳ細胞と確かめられれば、遺伝子を使わない新たな作製法となる。杉山教授は「ｉＰＳ細胞と特徴が似ている。さらに検証を進める」と話す。研究成果の論文は投稿中という。
　チームは、悪性リンパ腫の治療薬を加工し、特定の遺伝子の働きを活発にできる約３０種類の化合物を開発した。ｉＰＳ細胞は、さまざまな細胞や組織に変化する能力がある受精卵のような性質を持つ。
　このためチームは、化合物を一つずつ皮膚細胞に加え、受精卵に近い細胞の状態に変わるのに関わる遺伝子の働きを活発にするのは、どの化合物かを調べ、１種類を特定した。この化合物を皮膚細胞に加えて培養したところ、約３週間後にｉＰＳ細胞のような細胞の塊ができた。ｉＰＳ細胞に特有の酵素や、同様の高い増殖能力があり、見た目も似ているという。
　実用化に向けてｉＰＳ細胞なのかを詳しく検証する必要があるでしょうが遺伝子を用いずｉＰＳ細胞ができるようになるといいですね。