succeeded in producing iPS cells in human liver（iPS細胞で人間の肝臓を作り出すことに成功）

Such as that team was successful Yokohamashiritsudai that use cells (iPS) cells induced pluripotent stem cells have the ability to become various, creating a small human liver in the body of the mouse, was found in up to 8 days . There is a possibility that can be applied to treatment or organ transplantation in patients with liver failure was made, the development of pharmaceuticals.

Until now, research to make liver cells from human iPS cells were, making the organ with a complex three-dimensional structure has been difficult. Team for several days, and the addition of cell culture cells and in this cell, called "progenitor cells" in front of the iPS cells of human liver cell changes to make the blood vessels, a role that connects the cells together. Were transplanted into the head of the mouse, the source of the liver has grown to about 5 mm in diameter.

Then, could a network of blood vessels in the next few days. After two months to make a protein specific to human, such as the drug decomposition, it was confirmed that that works similar to the liver.

I will step up to a valuable practical application, but would have to go beyond the various wall.



さまざまな細胞になる能力がある人工多能性幹細胞（ｉＰＳ細胞）を使い、マウスの体内で人間の小さな肝臓を作り出すことに横浜市立大などのチームが成功したことが、８日までに分かった。肝不全の患者に作った臓器を移植する治療や、医薬品の開発に応用できる可能性がある。
これまでも、人のｉＰＳ細胞から肝細胞を作る研究はあったが、複雑な立体構造を持つ臓器を作るのは難しかった。チームは今回、人のｉＰＳ細胞が肝細胞に変わる手前の「前駆細胞」という細胞に、血管を作る細胞と、細胞同士をつなぐ役割をする細胞とを加えて数日間、培養。直径約５ミリに成長した肝臓のもとを、マウスの頭部に移植した。
すると、数日間で血管網ができた。２カ月後には人に特有のタンパク質を作り、薬物を分解するなど、肝臓と似た働きをすることを確認した。
　実用化までには様々な壁を超えていかなければならないでしょうが貴重な一歩でしょうね。