Specific enzymes play a major role in the metastasis of cancer cells(がん細胞の転移に大きな役割を果たす酵素を特定)

And to identify the enzyme plays a major role in the metastasis of cancer cells, a team of instructors Mochizuki was released in the U.S. magazine the National Cancer Institute of Medicine, Keio up to 21 days and Okada Professor (Pathology). Inhibition of this enzyme in mouse experiments, it was able to reduce the transition.

Cancer cells usually, but most die enters the vessel, spread to other organs survive a small part. Team, the degradation of VWF in the blood is a molecule called an enzyme called ADAM28 is working strongly in the cells of lung cancer or breast cancer, cancer cells was confirmed to be exempted from the cell death caused by this molecule.

When injected into mouse lung cancer cells the enzyme has not to work in genetic manipulation, compared to when administered to normal cell lung cancer, metastasis to the lung was reduced to one-sixth. When injected into the breast of breast cancer cell enzyme was not to work, could be suppressed to about one-fifth of the brain and kidney metastasis, lung, and liver to.

Means, I hope lead to the development of new drugs and treatment methods can suppress the metastasis promoting further research.


がん細胞の転移に大きな役割を果たす酵素を特定したと、慶応大医学部の岡田教授（病理学）と望月講師らのチームが２１日までに米国立がん研究所雑誌に発表した。マウスの実験でこの酵素の働きを阻害すると、転移を減らすことができたという。
　がん細胞は通常、血管に入るとほとんどが死滅するが、ごく一部が生き残って他の臓器に転移する。チームは、肺がんや乳がんの細胞で強く働いているＡＤＡＭ２８という酵素が血液中のＶＷＦという分子を分解し、がん細胞はこの分子が引き起こす細胞死を免れることを確認した。
　 遺伝子操作で酵素が働かないようにした肺がんの細胞をマウスに注射すると、通常の肺がん細胞を投与した場合に比べ、肺への転移が６分の１に抑えられた。酵 素が働かないようにした乳がんの細胞を乳房に注射した場合、脳や腎臓、肺、肝臓などへの転移も５分の１程度に抑制できた。
　ぜひ、更に研究を進めて転移を抑制できる治療方法や新薬の開発につなげて欲しいですね。