Development of production methods to increase to about 20 times that of the conventional.

To have been developed in mouse fabrication process to increase to about 20 times that of the conventional efficiency to make (iPS cells) induced pluripotent stem cells, a team such as RIKEN announced in the U.S. scientific journal electronic version dated 6. Team, focusing on the protein histone present in large amounts in the egg. When making iPS cells from somatic cells in mice, in addition to the 4 genes Shinya Yamanaka, Kyoto University professor found, incorporating two genes to make special histones. As a result, the ratio of iPS cells can be approximately 10 times that of the conventional. Was increased to about 20 times and also added protein to help the function of histone further. Protein to increase the efficiency is more I might be present. I want you to establish the technology of creating iPS cells were stable for clinical application.


人工多能性幹細胞（ｉＰＳ細胞）を作る効率を従来の約２０倍に上げる作製法をマウスで開発したと、理化学研究所などのチームが６日付の米科学誌電子版に発表した。チームは、卵子の中に大量に存在するタンパク質ヒストンに注目。マウスの体細胞からｉＰＳ細胞を作る際、山中伸弥京都大教授が発見した４遺伝子に加え、特殊なヒストンを作る２種類の遺伝子を組み込んだ。その結果、ｉＰＳ細胞ができる割合が従来の約１０倍に。さらにヒストンの働きを助けるタンパク質も加えると約２０倍に高まった。もっと効率を上げるたんぱく質が存在するのかもしれませんね。臨床応用に向けて安定したｉＰＳ細胞作成の技術を確立してほしいですね。