identify genes that interfere with the production of cell iPS.

announced from the lecturer Masui iPS Cell Institute, Kyoto University and found out experiments in mice, a gene that interfere with the preparation of iPS cells (induced pluripotent stem cells).
By weakening the function of these genes, there is a possibility that the cells can be produced efficiently iPS.
To introduce four genes into mature cells, it was back to a state close to a fertilized egg cells in iPS, it initializes a series of processes. However, the efficiency of production of iPS cells is usually as low as 1%.
Considered in the process of initialization, the genes active in neuronal cells and act in the way, from the instructor Masui, he examined the function of the gene 158. As a result, make sure that the six genes are inhibited initialization. And strengthen the function of these genes, efficient production of iPS cells, fell to one-fifth of the normal maximum. I want to establish a technology that can create iPS cells by further studies.


ｉＰＳ細胞（人工多能性幹細胞）の作製を邪魔する遺伝子を、京都大ｉＰＳ細胞研究所の升井講師らがマウスの実験で突き止めたと発表した。
　これらの遺伝子の働きを弱めることで、ｉＰＳ細胞を効率よく作製できる可能性がある。
　成熟した細胞に四つの遺伝子を導入し、受精卵に近い状態に戻したのがｉＰＳ細胞で、一連の過程を初期化という。ただ、ｉＰＳ細胞の作製効率は通常１％程度と低い。
　升井講師らは、初期化の過程で、神経細胞で活発に働く遺伝子が邪魔をしていると考え、１５８の遺伝子の働きを調べた。その結果、六つの遺伝子が初期化を阻害していることを確認。これらの遺伝子の働きを強めると、ｉＰＳ細胞の作製効率は、最大で通常の５分の１に落ちた。更に研究を進めてiPS細胞を作成できる技術を確立して欲しいですね。