ＣＣＬ―１

 To have been discovered in animal studies the cause of the severe pain caused nerve is damaged at the time of such terminal cancer called "neuropathic pain", Takano Professor of Fukuoka University (pharmacology) and others announced the 21st to the British science journal electronic version .
Said that cause protein called "CCL-1" is the increase in the spinal cord. Analgesics such as morphine are hardly braking effectiveness in this pain, it is expected to lead to new therapies.
As a result of intense pain reproduced by tying the sciatic nerve in mice, CCL-1 in the spinal cord is increased to two times the normal. Further, when injected CCL-1 to spinal cord of normal mice began to show even a little stimulation, the operation shown when he felt severe pain usually.
Meanwhile, it was also confirmed that there is a protective effect that you leave the injection advance substances prevent the action of CCL-1, no longer feels severe pain. It is a good treatment that can be prevention or mitigation of severe pain can is going to establish.



末期がんなどの際に神経が傷ついて起きる「神経障害性疼痛」という激痛の原因を動物実験で突き止めたと、福岡大学の高野教授（薬理学）らが英科学誌電子版に２１日発表した。
　脊髄で「ＣＣＬ―１」というたんぱく質が増えるのが原因だという。この疼痛にはモルヒネなどの鎮痛剤が効きにくいが、新たな治療法につながると期待される。
　マウスの座骨神経を縛って激痛を再現したところ、脊髄のＣＣＬ―１が通常の２倍に増加した。また、正常なマウスの脊髄にＣＣＬ―１を注射すると、通常は激痛を感じた時に示す動作を、少しの刺激でも見せるようになった。
　一方、ＣＣＬ―１の働きを妨げる物質をあらかじめ注射しておくと、激痛を感じなくなる予防効果があることも確認した。激痛の緩和できたり予防できる治療法が確立していくといいですね。