Rats with severe diabetes improvement.

Decided to create a new cell that combines the islet cells in the pancreas that secrete insulin to lower the blood glucose level, the stem cells with proliferative capacity, and improve and transplanted into rats with severe diabetes angle Associate Professor of Kyoto University (regenerative medicine team) is successful, I announced the U.S. online science journal Purosuwan.
In severe cases, there is a treatment of transplanting islets organ donor with diabetes that occurs, such as insulin deficiency, but providers need more than one in order to obtain a sufficient effect in many cases, a chronic shortage. The present method, effective, high insulin secretion lasts longer than transplantation of islets only, development is expected as a new treatment.
Ability of cell death inhibition and cell proliferation is high located in the bone marrow, the team focused on cell mesenchymal stem also has ability to become different cell. And mesenchymal stem cells were cultured and harvested from rats galvanized islet cells were fused by breaking the cell membrane. The transplanted to rats with severe diabetes, the fused cells, blood glucose level continues to fall over a period of about three months. It is good when it comes to good news for patients with diabetes, but I want spurred research to Tadoritsukeru in clinical trials.


血糖値を下げるインスリンを分泌する膵臓の膵島細胞と、増殖能力を持つ幹細胞を融合させた新たな細胞を作り、重症糖尿病のラットに移植して改善させることに京都大の角准教授（再生医療）のチームが成功し、米オンライン科学誌プロスワンに発表した。
　インスリン不足などで起きる糖尿病では重症の場合、臓器提供者の膵島を移植する治療があるが、十分な効果を得るには複数の提供者が必要なことが多く、慢性的に不足。今回の手法は、膵島だけの移植よりインスリン分泌が長く続き効果が高く、新たな治療法として開発が期待される。
　チームは、骨髄の中にあり細胞増殖や細胞死抑制の能力が高く、さまざまな細胞になる能力も持つ間葉系幹細胞に注目。ラットから採取して培養した間葉系幹細胞と、膵島細胞に電流を通し、細胞膜を壊して融合させた。融合細胞を、重症糖尿病のラットに移植、約３カ月にわたり血糖値が下がり続けた。糖尿病の患者にとって朗報になるといいですが臨床試験にたどり着けるように研究に拍車をかけて欲しいですね。