first demonstrated that iPS cells continues to move as myocardial tissue.

That myocardial infarction transplanted into rats were allowed to develop artificial pluripotent stem cells (iPS cells) were assimilated and portability destination of heart, research groups, such as Osaka University is proved at the molecular level, the US science journal until the 26th I announced to. The same day, Sawa professor of the university of Cardiovascular Surgery, which was met with Osaka University Graduate School of Medicine (Suita, Osaka Prefecture) Unlike the "other cell transplantation, iPS cells were able for the first time demonstrated that continues to move as myocardial tissue. it was said that we want to "lead to clinical in humans.
Previously, domestic or foreign animal experiments, but the iPS cells derived from that improve cardiac function by transplanting the heart has been reported, to exercise by assimilated actually ported destination heart has been demonstrated did not.
In the experiment, using iPS cells derived from mice transplanted cardiomyocytes cultured sheet of about 1 cm diameter 5 rats. About by irradiating a strong electromagnetic wave after one month was examined the motion of cardiac muscle contractile protein molecules that cardiomyocytes derived from transplanted iPS cells was confirmed that it is repeatedly extended and stretch assimilated with the heart. I want to hope that it becomes able to have early to clinical stage can be to human advances the further research.




心筋梗塞を発症させたラットに移植した人工多能性幹細胞（iPS細胞）が移植先の心臓と同化したことを、大阪大学などの研究グループが分子レベルで証明し、26日までに米科学誌に発表した。同日、阪大医学系研究科（大阪府吹田市）で会見した同大心臓血管外科の沢教授は「他の細胞移植とは異なり、iPS細胞が心筋組織として動き続けることが初めて証明できた。ヒトでの臨床につなげていきたい」と述べた。
　これまで、国内外の動物実験により、iPS由来細胞を心臓に移植することで心機能が改善することは報告されていたが、実際に移植先の心臓と同化して運動することは証明されていなかった。　
　実験では、マウス由来のiPS細胞を用いて、直径1センチほどの心筋細胞培養シートをラット5匹に移植。約1カ月後に強力な電磁波を照射して心筋収縮タンパク質分子の運動を調べたところ、移植したiPS細胞由来の心筋細胞が心臓と同化して伸縮と拡張を繰り返していることが確認できたという。更なる研究を進めて人間への臨床が出来る段階まで早期に持っていけるようになることを期待したいですね。