Substance in the body that exacerbate the hypertrophic cardiomyopathy.

Wall of the heart becomes thicker, from systemic to a patient's difficult to become hypertrophic cardiomyopathy send out blood induced pluripotent stem cells (iPS cells) to make the heart muscle cells, and have found a substance in the body that aggravate the disease, of Keio University School of Medicine Professor Fukuda, Yuasa full-time lecturer from July 12, was announced to the American Heart Association journal.
I and also found that there is a possibility that the existing drugs to improve the condition.
Inside the healthy human heart muscle cells, the protein of the filamentous called myofibrils are arranged orderly, was disturbed are aligned in patients with myocardial cells. But is disturbed and the addition of a substance called endothelin-1 became badly, given the medicine in which the cells are to refuse to accept this material, abnormality has healed.
It is felt that research and experience that you take advantage of iPS cells came out with certainty. Come, I will expect that the specific and treatment of various diseases is gradually been located.


心臓の壁が厚くなり、全身に血液を送り出しにくくなる肥大型心筋症の患者の人工多能性幹細胞（ｉＰＳ細胞）から心筋細胞を作り、病気を悪化させる体内物質を突き止めたと、慶応大医学部の福田教授、湯浅専任講師らが１２日、米心臓協会誌に発表した。
　既存の薬が状態を改善する可能性があることも分かったとしている。
　健康な人の心筋細胞の内部では、筋原線維という糸状のタンパク質が整然と並んでいるが、患者の心筋細胞では並びが乱れていた。エンドセリン１という物質を加えると乱れがひどくなったが、細胞がこの物質を受け取れないようにする薬を与えると、異常が治った。
　iPS細胞の活用した研究や実績が確実に出てきた感じですね。ぜひ、様々な病気の特定や治療法が突き止められていくことを期待します。