Possibility to find a small amount of blood.

Research team, such as the National Chojuiryokenkyusenta is, before the onset of Alzheimer's disease, announced that it had found the mark in the blood that cause protein of the state is known.
In results that lead to the possibility to find the signs of the onset with a small amount of blood, to be published in scientific journals of the date 11 Japan Academy.
Alzheimer's disease, cause protein "amyloid β beta" accumulates in the brain, the brain is to occur to atrophy. Amyloid β is thought to require 15-20 years to develop from the start to accumulate.
Conventionally, to examine the accumulation of amyloid β in the brain, or greater burden of patients, such as to refer the needle to collect the cerebrospinal fluid in the spinal cord, extensive diagnostic imaging equipment was a challenge to or needed.
In this study, it is possible to investigate the increase and decrease of the amyloid-β-related substances in trace amounts in the blood, found that it is possible to confirm the accumulation of amyloid β in the brain. The results of the analysis to target the 62 people of 65-85 years of age, including a person not in Alzheimer's disease and so was consistent with the results and 92% or more of the accuracy of diagnostic imaging in the brain that went in advance. Toward the practical use, and I want to proceed with further research.


国立長寿医療研究センターなどの研究チームは、アルツハイマー病の発症前に、原因たんぱく質の状態が分かる血液中の目印を見つけたと発表した。
　発症の兆候を少量の血液で見つける可能性につながる成果で、１１日付の日本学士院の学術誌に掲載される。
　アルツハイマー病は、原因たんぱく質「アミロイドβベータ」が脳内にたまり、脳が萎縮して起こるとされる。アミロイドβが蓄積し始めてから発症までに１５～２０年要すると考えられている。
　脳内のアミロイドβの蓄積を調べるには従来、脊髄に針を刺して脳脊髄液を採取するなど患者の負担が大きかったり、大がかりな画像診断機器が必要だったりするのが課題だった。
　今回の研究では、血液中の微量のアミロイドβ関連物質の増減を調べることで、脳内のアミロイドβの蓄積を確認できることが判明。アルツハイマー病やそうでない人を含む６５～８５歳の６２人を対象に解析した結果、事前に行った脳内の画像診断の結果と９２％以上の精度で一致した。実用化に向けて、更なる研究を進めて欲しいですね。