"Needleless syringe"

The development of "needleless syringe" as deliver reagents and gene into the body at a pressure of bubbles without a needle, Shanxi, Associate Professor of Mechanical Engineering, Shibaura Institute of Technology was successful. Direct only pressed against the skin, that the reagents and gene painlessly be transported with high precision to the desired location.
No existing needleless syringe is fired at high pressure the liquid by the force of the spring, there are such as to administer a drug to muscle through the skin, fear and hurt nerves, there is a problem such as feeling less pain was.
New development needleless syringe, it opened the fine hole in the skin with a force bubble that was fired at a high speed burst, from the hole, to inject a fine bubbles wearing a reagent. Gas bubbles are contracted, only the reagent reaches the affected area. The diameter of the hole as much as 4μ meters, I need also less damage to the cells.
2012 was developed to improve the "micro bubble injection female" developed in years. Microbubble injection females, launched in succession the fine bubbles in the liquid, and at the same time leave the fine pores of the micro-level, it is possible to transport the bubbles wearing a reagent female. The position of the glass shell over a female to improve the adhesion between the cell and the bubble introducing portion by projecting forward and to be used in air.
In addition to the drug available at the time of subcutaneous injection, such as gene transfer and treatment to all hardness of cells, including plant cells that can be used in a wide range of applications. Optimization of the device structure in the future, the amount of introduction of reagents, is carried out pain, the evaluation of drilling depth, with the aim of practical use by, for example, to work with the company. I injection is a good painless. Come and I want you to put to practical use.


針を使わずに気泡の圧力で試薬や遺伝子を体内に届けられる「針なし注射器」の開発に、芝浦工業大学機械工学科の山西准教授が成功した。直接皮膚に押し当てるだけで、痛みを伴わずに試薬や遺伝子を目的の場所へ高精度に輸送できるという。
　既存の針なし注射器は、バネの力で液体を高圧で発射し、皮膚を貫いて筋肉に薬剤を投与するものなどがあるが、神経を傷つける恐れや、多少の痛みを感じるなどの問題があった。
　新開発の針なし注射器は、高速で発射した気泡がはじける力で皮膚に微細な穴を空け、その穴から、試薬をまとった微細な気泡を注入する。気泡のガスは収縮し、試薬だけが患部に届く。穴の直径は4μメートルほどで、細胞へのダメージも少なくて済む。
　2012年に開発した「マイクロバブルインジェクションメス」を改良して開発した。マイクロバブルインジェクションメスは、液中で微細な気泡を連続して打ち出し、マイクロレベルの微細な穴を空けると同時に、試薬をまとった気泡を輸送できるメス。メスを覆うガラス製のシェルの位置を前方に突き出すことで細胞と気泡導入部との密着性を向上させ、空気中で使用できるようにした。
　薬剤を皮下注射する際に利用できるほか、植物細胞を含むあらゆる固さの細胞への遺伝子導入・治療など、幅広い用途に使用できるという。今後はデバイス構造の最適化、試薬の導入量、痛み、穿孔深度の評価を行い、企業と連携するなどして実用化を目指す。痛みのない注射良いですね。ぜひ、実用化して欲しいですね。